The earliest evidence of ecclesiastical territories in the present territory of the Metropolis of Thessaliotis and Fanariofersala appeared after the middle of the fourth or early fifth century when a Bishop Perrevio of the diocese of Farsala, that was subordinate to the Metropolis of Larissa, took part in the Council of Ephesus in 431. In the ninth century, a Bishop Stephen of Farsala attended a meeting with Patriarch Photius in 879.