In the 2nd century BC, an attempt by Antiochus IV of the Seleucid Empire to abolish Judaism for a Hellenistic religion sparked the Maccabean Revolt, led by Judas Maccabeus. The uprising ended the Greek rule, and Maccabeus' victory is celebrated in the festival of Hanukkah.
Insurrections within the region continued for centuries. The First Jewish Revolt in 66 AD, against the Roman Empire, ended with the defeat of the Jews, dispersing much of the population to other areas around the Mediterranean, and forcing the remaining to be sold into slavery.